Donald J Buchsbaum Selected Research

TNF-Related Apoptosis-Inducing Ligand Receptors

1/2018	Calmodulin antagonist enhances DR5-mediated apoptotic signaling in TRA-8 resistant triple negative breast cancer cells.
11/2016	Characterization of the interactions between calmodulin and death receptor 5 in triple-negative and estrogen receptor-positive breast cancer cells. AN INTEGRATED EXPERIMENTAL AND COMPUTATIONAL STUDY.
10/2016	Characterization of the Interactions between Calmodulin and Death Receptor 5 in Triple-negative and Estrogen Receptor-positive Breast Cancer Cells: AN INTEGRATED EXPERIMENTAL AND COMPUTATIONAL STUDY.
1/2016	A Novel Imaging Biomarker Extracted from Fluorescence Microscopic Imaging of TRA-8/DR5 Oligomers Predicts TRA-8 Therapeutic Efficacy in Breast and Pancreatic Cancer Mouse Models.
4/2011	Mechanisms of drug sensitization to TRA-8, an agonistic death receptor 5 antibody, involve modulation of the intrinsic apoptotic pathway in human breast cancer cells.
7/2009	Effect of TRA-8 anti-death receptor 5 antibody in combination with chemotherapy in an ex vivo human ovarian cancer model.
10/2008	Early therapy evaluation of combined anti-death receptor 5 antibody and gemcitabine in orthotopic pancreatic tumor xenografts by diffusion-weighted magnetic resonance imaging.
8/2008	Combination of treatment with death receptor 5-specific antibody with therapeutic HPV DNA vaccination generates enhanced therapeutic anti-tumor effects.
6/2008	Enhancement of glioma radiotherapy and chemotherapy response with targeted antibody therapy against death receptor 5.
4/2008	Treatment of human colon cancer xenografts with TRA-8 anti-death receptor 5 antibody alone or in combination with CPT-11.

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Donald J Buchsbaum Research Topics

Disease

114	Neoplasms (Cancer) 01/2022 - 02/2002
32	Pancreatic Neoplasms (Pancreatic Cancer) 01/2021 - 02/2002
24	Ovarian Neoplasms (Ovarian Cancer) 01/2020 - 06/2004
20	Breast Neoplasms (Breast Cancer) 10/2020 - 09/2003
9	Carcinoma (Carcinomatosis) 01/2014 - 03/2002
8	Triple Negative Breast Neoplasms 10/2020 - 08/2011
8	Adenocarcinoma 01/2018 - 12/2004
6	Carcinogenesis 01/2022 - 03/2009
6	Ascites 01/2020 - 09/2013
6	Neoplasm Metastasis (Metastasis) 03/2018 - 12/2004
6	Glioma (Gliomas) 12/2017 - 02/2002
6	Prostatic Neoplasms (Prostate Cancer) 12/2015 - 02/2002
3	Glioblastoma (Glioblastoma Multiforme) 12/2017 - 02/2002
3	Ovarian Epithelial Carcinoma 05/2017 - 06/2009
3	Colonic Neoplasms (Colon Cancer) 04/2013 - 04/2008
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 04/2007 - 03/2003
2	Colorectal Neoplasms (Colorectal Cancer) 01/2018 - 01/2017
2	Inflammation (Inflammations) 01/2017 - 03/2009
2	Necrosis 01/2016 - 10/2013

Drug/Important Bio-Agent (IBA)

30	Monoclonal AntibodiesIBA 03/2018 - 02/2002
22	tigatuzumabIBA 01/2018 - 09/2003
19	LigandsIBA 12/2019 - 03/2002
18	Proteins (Proteins, Gene)FDA Link 12/2018 - 02/2002
16	TNF-Related Apoptosis-Inducing Ligand ReceptorsIBA 01/2018 - 04/2006
14	Pharmaceutical PreparationsIBA 01/2022 - 03/2003
13	CateninsIBA 01/2020 - 01/2013
11	Gemcitabine FDA Link 01/2018 - 11/2002
11	ErbB Receptors (EGF Receptor)IBA 06/2011 - 11/2002
10	Death Domain ReceptorsIBA 01/2017 - 08/2006
10	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2011 - 10/2002
8	Carboplatin (JM8)FDA LinkGeneric 04/2017 - 07/2009
7	AntibodiesIBA 01/2020 - 10/2005
7	Peptides (Polypeptides)IBA 01/2013 - 02/2002
7	Cetuximab (Erbitux)FDA Link 06/2011 - 11/2002
6	EnzymesIBA 01/2021 - 02/2002
6	Radioisotopes (Radionuclides)IBA 01/2020 - 02/2002
6	Messenger RNA (mRNA)IBA 12/2018 - 02/2002
6	Niclosamide FDA Link 10/2018 - 04/2014
6	RNA (Ribonucleic Acid)IBA 01/2017 - 02/2006
5	AntigensIBA 09/2020 - 03/2003
5	Paclitaxel (Taxol)FDA LinkGeneric 01/2020 - 03/2003
5	Adenosine Triphosphate (ATP)IBA 02/2016 - 05/2007
5	Biomarkers (Surrogate Marker)IBA 02/2016 - 11/2012
5	Epidermal Growth Factor (EGF)IBA 08/2010 - 11/2002
4	Calmodulin (Calcium-Dependent Activator Protein)IBA 01/2018 - 10/2016
4	Estrogen ReceptorsIBA 01/2017 - 07/2014
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 02/2015 - 08/2002
4	PlatinumIBA 01/2014 - 10/2010
4	Tyrosine Kinase InhibitorsIBA 01/2014 - 04/2007
4	Irinotecan (Camptosar)FDA LinkGeneric 04/2013 - 09/2007
4	Doxorubicin (Adriamycin)FDA LinkGeneric 06/2012 - 09/2003
4	Cisplatin (Platino)FDA LinkGeneric 10/2011 - 04/2006
4	Erlotinib Hydrochloride (CP 358,774)FDA Link 11/2007 - 04/2007
4	Somatostatin Receptors (Somatostatin Receptor)IBA 01/2005 - 02/2002
3	Phenobarbital (Luminal)FDA Link 10/2020 - 08/2011
3	CytokinesIBA 09/2020 - 03/2005
3	Histone Deacetylase InhibitorsIBA 12/2019 - 07/2017
3	TNF-Related Apoptosis-Inducing LigandIBA 03/2017 - 08/2007
3	CaspasesIBA 01/2017 - 08/2002
3	Metalloproteases (Metalloproteinases)IBA 02/2014 - 01/2009
3	taxaneIBA 01/2014 - 10/2010
3	DNA (Deoxyribonucleic Acid)IBA 10/2013 - 04/2007
3	Small Interfering RNA (siRNA)IBA 04/2013 - 06/2009
3	LuciferasesIBA 07/2012 - 10/2008
3	Bevacizumab (Avastin)FDA Link 02/2011 - 06/2009
3	Biological ProductsIBA 08/2010 - 08/2006
3	Cytosine DeaminaseIBA 09/2008 - 02/2002
3	Pentetic Acid (DTPA)FDA LinkGeneric 03/2002 - 02/2002
2	GlycosyltransferasesIBA 01/2021 - 01/2016
2	Sialic AcidsIBA 01/2021 - 01/2016
2	Transcription Factors (Transcription Factor)IBA 10/2020 - 01/2016
2	LGK974IBA 01/2020 - 02/2016
2	entinostat (MS 275)IBA 12/2019 - 12/2018
2	benzimidazoleIBA 05/2018 - 01/2017
2	Indicators and Reagents (Reagents)IBA 03/2018 - 01/2006
2	SRI36160IBA 01/2018 - 01/2017
2	A-Form DNA (A-DNA)IBA 07/2017 - 08/2008
2	EpitopesIBA 04/2017 - 01/2014
2	Mechanistic Target of Rapamycin Complex 1IBA 01/2017 - 07/2014
2	CalciumIBA 01/2017 - 10/2016
2	Glycoproteins (Glycoprotein)IBA 01/2016 - 11/2005
2	Caspase 3 (Caspase-3)IBA 02/2015 - 03/2005
2	Phosphotransferases (Kinase)IBA 02/2015 - 07/2009
2	Therapeutic UsesIBA 08/2014 - 01/2004
2	Membrane Proteins (Integral Membrane Proteins)IBA 07/2014 - 06/2009
2	beta-lapachoneIBA 02/2014 - 10/2013
2	Basigin (Extracellular Matrix Metalloproteinase Inducer (EMMPRIN))IBA 02/2014 - 06/2009
2	NAD (NADH)IBA 10/2013 - 11/2009
2	RetinoidsIBA 04/2012 - 02/2012
2	Phosphates (Orthophosphate)IBA 06/2011 - 02/2011

Therapy/Procedure

55	Therapeutics 10/2020 - 02/2002
29	Drug Therapy (Chemotherapy) 01/2018 - 02/2002
14	Radiotherapy 01/2020 - 02/2002
7	Radioimmunotherapy 01/2020 - 01/2004
5	Immunotherapy 09/2020 - 08/2008
3	Aftercare (After-Treatment) 02/2016 - 09/2007
3	Injections 04/2012 - 02/2002
2	Lasers (Laser) 01/2016 - 04/2007
2	Cytoreduction Surgical Procedures 09/2013 - 05/2007
2	Secondary Prevention 06/2011 - 10/2008